I am not a vet- nor do I play one on tv but for all of my Google-ing all I can come up with is that she is stressed.
Calico is not the nicest of felines. She likes you or she doesn't and she prefers to be petted on her terms and only on her terms.
She is a fluffy- meaning- well she is big boned- okay okay she is fat. She was not always fat. I swear. When I rescued her she was thin- then she broke her toe, then ran away, and came back a scraggly skinny mangy thing but now she has made up for her month of deprivation and has extra padding.
Her issue now is she is scratching herself raw- in more than one area. She does not have fleas, she does not have a rash that I can see but she scratches until she is bleeding. Then it scabs over and she scratches the scab off. So far she has four areas on her head/neck that she has scratched raw.
Giving cats pills is not a pleasure in my experience and I am afraid that she would need xanax to relieve the anxiety of getting a pill shoved down her throat. That or I would need body armor.
There is something odd and counter-intuitive about giving a cat (or any animal) psychotropic medication (in my opinion). Somehow it seems that their psyches should be less complex and less messy.
What does she have to be stressed about? Hair balls? Laying in the sun?